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Antimicrobial Bone Graft Substitute

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
73716
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
A043-190-1151
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NANOTHERAPEUTICS, INC.
13859 Progress Blvd. ALACHUA, FL -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Antimicrobial Bone Graft Substitute
Agency / Branch: DOD / ARMY
Contract: W81XWH-05-C-0062
Award Amount: $69,938.00
 

Abstract:

In this Phase I SBIR project, Nanotherapeutics proposes to utilize its proprietary particle delivery systems to develop an injectable bone paste formulation incorporating an anti-microbial (PHMB) as a bone graft substitute. A solution-based system, GraftonT (Osteotech) and, recently, a dry osteconductive powder available for reconstitution, OSTEOFILT, became available as superior bone grafts, but each with drawbacks. A new composition incorporating gelatin-coated particles, NanopasteTM (produced by Nanotherapeutics, Inc., patent pending), which has excellent syringability, has proven to be osteconductive in animal studies and is currently licensed (undisclosed). This composition is particulary suitable for incorporation of additional anti-microbial materials, such as PHMB, which may be simply physically mixed in or encapsulated to produce slow-release over days. Using its proprietary powder processing technologies, sustained-release PHMB / NanopasteTM formulations will be tested with significant advantages over standard bone graft materials. In this six month Phase I project, preparation of PHMB / NanopasteTM formulations and in vitro characterization and release will be performed, and preparation for in vivo animal studies to test the efficacy in rodents will be conducted.

Principal Investigator:

James D. Talton
President and CEO
3864629663
jtalt@nanotherapeutics.com

Business Contact:

James D. Talton
President and CEO
3864629663
jtalt@nanotherapeutics.com
Small Business Information at Submission:

NANOTHERAPEUTICS, INC.
12085 Research Dr Ste N, Suite N Alachua, FL 32615

EIN/Tax ID: 593615370
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No