Resting normal cells do not express interleukin-2 receptor (IL-2R). The receptor is expressed bysome of the activated cells such as those in certain forms of lymphoid malignancies, autoimmunediseases, and graft rejection. Taking advantage of this property of IL-2R, several IL-2R directed… More

This Phase I is designed to test feasibility of developing immunotoxins for human lymphoidleukemia using IL-2 and either 90Y or 131I. There is ample evidence that many cases of humanleukemia are cytokine-dependent. The Principal Investigator has long experience in the study… More

DESCRIPTION (Adapted from applicant's abstract): This project will test the feasibility of using a new gene transfer device to transfect primary human blood progenitors, in vitro. The genetically modified blood precursor cells will be reintroduced by autologous transfusion and permitted to… More

Bacterial pathogens in salmonids, such as Renibacterium salmoninarum and Aeromonas salmonicida, are difficult to identify by conventional diagnosis due to their extremely slow growth and the absence of an efficient selective medium. Diseases caused by these pathogens represent a serious problem… More

Not Available Bacterial pathogens in salmonids, such as Renibacterium salmoninarum and Aeromonas salmonicida, are difficult to identify by conventional diagnosis due to their extremely slow growth and the absence of an efficient selective medium. Diseases caused by these pathogens represent a… More