Award Year / Program / Phase:2009 / SBIR / Phase I
Agency:HHS
Principal Investigator:Dallas Bednarczyk
Award Amount:$406,969.00
Abstract:
DESCRIPTION (provided by applicant): Transporters are a class of more than 300 membrane proteins that regulate how nutrients and drugs enter and leave biological cells. Transporters have validated clinical significance and affect every aspect of drug ADMET
(Absorption, Distribution, Metabolism,… More
DESCRIPTION (provided by applicant): Desirable drug ADME (Absorption, Disposition, Metabolism and Elimination) properties are key determinants of a drug's to safety and efficacy. Unfortunately, poor ADME and Toxicity attributes have caused more drug failur
es than any other factors. There is a… More
DESCRIPTION (provided by applicant): Transporters are a class of more than 1000 membrane proteins that regulate how nutrients and drugs enter and leave biological cells. Transporters have validated clinical significance and affect every aspect of drug ADME(Absorption, Distribution, Metabolism,… More
Award Year / Program / Phase:2011 / SBIR / Phase I
Agency:HHS
Principal Investigator:Juan J. Fung – 650-725-7754
Award Amount:$150,000.00
Abstract:
DESCRIPTION (provided by applicant): CNS Transporters have crucial roles on neurophysiology and etiology. Inhibition of these critical transporters can have therapeutic benefits or cause serious side effects in the CNS. Development of an assay platform anda comprehensive profile of drugs'… More