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NEURON2GPU: Transformative Neural Simulation Using Desktop GPU Technology

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
 Program Year/Program:
2011 / SBIR
Agency Tracking Number:
R43MH088129 		Solicitation Year:
2011 		Solicitation Topic Code:
NIMH 		Solicitation Number:
PA08-071
Small Business Information
INFORMED SIMPLIFICATIONS, LLC
520 PANORAMA RD EARLYSVILLE, VA 22936-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: NEURON2GPU: Transformative Neural Simulation Using Desktop GPU Technology
Agency: HHS
Contract: 1R43MH088129-01A1
Award Amount: $697,282.00
 

Abstract:

DESCRIPTION (provided by applicant): Researchers are now able to perform computational physiology and pharmacology experiments on realistic model neurons with accurate geometries and full complements of membrane biophysics and biochemistry; however, the practical utility of such simulations are restricted because of the limitations of current commodity computer hardware. We will provide real time, or better, simulations of realistic single neurons and clusters of neurons for drug discovery and physiology research by implementing neural simulation software on low-cost GPU-based desktop supercomputers. For the first time, our product will put the ability to quickly generate parameter landscapes of realistic neural and neural network function on the desks of students and scientists participating in basic research and drug discovery. Our technology will enable physiologists to use online modeling during imaging and electrophysiology experiments via predicting and tuning appropriate experimental manipulations. Inits fully developed form, the mature technology will provide realistic neural simulations - across parameter space - which then will be used to modify the parametric control of an ongoing experiment. PUBLIC HEALTH RELEVANCE: We propose to change thelandscape of computational neuroscience by putting high-throughput simulation software on the desktops of researchers at low cost. This work will enable not just advances in basic neuroscience leading to a better understanding of how the brain works in health and disease, but it will also provide tools for principled drug discovery for the treatment of human brain disease.

Principal Investigator:

Costa M. Colbert
650-261-1369
ccolbert@dslextreme.com

Business Contact:

William Levy
410-741-3618
wlevy@informedsimplifications.com
Small Business Information at Submission:

INFORMED SIMPLIFICATIONS, LLC
520 PANORAMA RD EARLYSVILLE, VA 22936-

EIN/Tax ID: 120378106
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No