USA flag logo/image

An Official Website of the United States Government

Novel Optrode Devices for Neuroscientists: Packaging and Waveguide Solutions to…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
R43NS073185
Solicitation Year:
2011
Solicitation Topic Code:
NINDS
Solicitation Number:
PA07-389
Small Business Information
NEURONEXUS TECHNOLOGIES
3985 RESEARCH PARK DR ANN ARBOR, MI -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: Novel Optrode Devices for Neuroscientists: Packaging and Waveguide Solutions to M
Agency: HHS
Contract: 1R43NS073185-01
Award Amount: $175,576.00
 

Abstract:

DESCRIPTION (provided by applicant): The objective of this application is to develop advanced optrode solutions for neuroscientists that fulfill the potential of optogenetic technology-achieving highly specific neural circuit control. Once developed, the neuroscientist's experimental options for optical stimulation will grow to two dimensions with no limits on the recording site placement. Our approach develops (i) practical, yet novel solutions for the packaging issues currently plaguing users, and (ii) custom waveguides capable of region-specific illumination with no electrical artifact, and is modularly integrated onto any existing NeuroNexus recording array. As an alternative to wafer- level integration, we have devised an approach that lowers cost by improving yield while increasing design options. This project will further optogenic techniques, which have shown excellent promise as tools that allow temporally precise, non-invasive control of activity in well- defined neuronal populations. This degree ofcontrol over neural firing allows specific monitoring of temporal activity patterns in the context of circuit dynamics, understanding changes due to plasticity, and responses to behavior and external cues, which is critically important for studying disease models as well. PUBLIC HEALTH RELEVANCE: The objective of this application is to develop advanced optrode solutions for neuroscientists that fulfill the potential of optogenetic technology-achieving highly specific neural circuit control. Once developed, the neuroscientist's experimental options for optical stimulation will grow to two dimensions with no limits on the recording site placement. Our approach develops (i) practical, yet novel solutions for the packaging issues currently plaguing users, and (ii) custom waveguides capable of region-specific illumination with no electrical artifact, and is modularly integrated onto any existing NeuroNexus recording array. As an alternative to wafer- level integration, we have devised an approach that lowers cost by improving yield while increasing design options. This project will further optogenic techniques, which have shown excellent promise as tools that allow temporally precise, non-invasive control of activity in well- defined neuronal populations. This degree of control over neural firing allows specific monitoring of temporal activity patterns in the context of circuit dynamics, understanding changes due to plasticity, and responses to behavior and external cues, which is critically important for studying disease models as well.

Principal Investigator:

John P. Seymour
734-936-3341
john@neuronexustech.com

Business Contact:

John P. Seymour
734-913-8858
john@neuronexustech.com
Small Business Information at Submission:

NEURONEXUS TECHNOLOGIES
3985 RESEARCH PARK DR ANN ARBOR, MI -

EIN/Tax ID: 120139860
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No