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ACPHARIS
UEI: E4Z3M7L7NHT3
# of Employees: 2
HUBZone Owned: No
Socially and Economically Disadvantaged: No
Woman Owned: No
Award Charts
Award Listing
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Deep learning augmented protein mapping software to screen large compound libraries
Amount: $173,006.00Fragment based drug discovery starts with screening libraries of fragment-sized organic molecules for binding to the target protein. The fragments cluster at binding hot spots, the most important regi ...
SBIRPhase I2022Department of Health and Human Services National Institutes of Health -
Software for Antibody Epitope Prediction
Amount: $149,999.00Accurate epitope prediction is important for the development of antibody based therapiesWhen multiple new antibodies are discovered against the whole antigentheir epitopes andthereforepotential novelt ...
SBIRPhase I2019Department of Health and Human Services National Institutes of Health -
Knowledge based Extensions of Protein Protein Docking
Amount: $150,000.00Protein protein interactions are involved at multiple points in nearly all biological pathways Since determining the structure of protein complexes by X ray crystallography is expensive and slow it ...
SBIRPhase I2017Department of Health and Human Services National Institutes of Health -
Development of Structure Based Potential for Protein Mapping
Amount: $204,249.00The binding sites of proteins include smaller regions called hot spots that are major contributors to the binding free energy and hence are crucial to binding any ligand at that site Hot spots can b ...
STTRPhase I2017Department of Health and Human Services National Institutes of Health -
Design of target-specific libraries for fragment based drug discovery
Amount: $225,000.00DESCRIPTION provided by applicant Fragment based drug discovery FBDD is a combinatorial approach in which individual fragments binding to regions of the target site ar selected from a f ...
SBIRPhase I2016Department of Health and Human Services National Institutes of Health -
Software for Fragment-based Design of Covalent Inhibitors
Amount: $225,000.00DESCRIPTION (provided by applicant): Covalent drugs represent a significant portion of current pharmaceuticals, with the top 26 having sales of over 30B in the US alone. While in the past target-dire ...
SBIRPhase I2014Department of Health and Human Services National Institutes of Health -
SOFTWARE FOR MODELING AND OPTIMIZATION OF PROTEIN THERAPEUTICS
Amount: $149,999.00DESCRIPTION: Therapeutic proteins, including antibodies and other scaffolds such as DARPins and affibodies have become important drugs to treat cancer, infectious and cardiovascular diseases, arthriti ...
SBIRPhase I2013Department of Health and Human Services National Institutes of Health -
GPU Accelerated Protein Docking Software with Flexible Refinement
Amount: $104,898.00DESCRIPTION (provided by applicant): Protein-protein interactions are involved at multiple points in virtually all biological pathways. Understanding such interactions is also important for the design ...
STTRPhase I2012Department of Health and Human Services National Institutes of Health -
High-throughput portable software for fragment-based drug design
Amount: $98,055.00DESCRIPTION (provided by applicant): Fragment-based drug design (FBDD) is a combinatorial approach in which individual fragments binding to regions of the target site are selected from a fragment libr ...
STTRPhase I2011Department of Health and Human Services National Institutes of Health