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A Device To Quantify Sweat Of Single Sweat Glands To Diagnose Neuropathy

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / STTR
Agency Tracking Number:
R41NS071979
Solicitation Year:
2011
Solicitation Topic Code:
NINDS
Solicitation Number:
PA10-051
Small Business Information
NEURO DEVICES, INC.
4103 E LAKE ST MINNEAPOLIS, MN 55406-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: A Device To Quantify Sweat Of Single Sweat Glands To Diagnose Neuropathy
Agency: HHS
Contract: 1R41NS071979-01A1
Award Amount: $203,014.00
 

Abstract:

DESCRIPTION (provided by applicant): Neuro Devices, Inc. will construct a dynamic sweat test (DST) for early detection of peripheral neuropathy. Neuropathy is detected by measuring the rate and volume of sweat secreted by single sweat glands (SGs) under the control of sudomotor nerves. The test has a major advantage over other tests of nerve function because SGs are accessible for analysis on distal sites of the hands and feet where the first signs of neuropathy appear. Device feasibility will be testedby comparing results from testing healthy control subjects and cancer patients with chemotherapy induced peripheral neuropathy (CIPN). Physicians at the M.D. Anderson hospital, Houston will add the DST to their extensive sensory testing of patients duringchemotherapy that they perform to detect the initial signs of neuropathy. Early detection is beneficial because the potential for recovery declines with progressive nerve degeneration. Early diagnosis also provides the opportunity to decide if the chemotherapeutic agent should be decreased in dosage, discontinued, substituted or, when no neuropathy is detected, if chemotherapy can be increased to more effective cancer killing dosage. Existing sensory tests lack this sensitivity for early detection of minimal nerve abnormality. The dynamic sweat test (DST) device is a measure of the vitality of the sudomotor nerves that stimulate sweating. SGs whose nerves have degenerated cannot secrete water. Partially denervated and reinnervating SGs secrete smaller thannormal sweat droplets. The DST measures SG density, distribution and total water volume. The DST also quantifies rate of sweating and amount of water of single SGs. This has an advantage over existing sweat tests that only measure total water produced at askin location because sweating by normally secreting SGs can obscure a deficiency in a smaller number of partly or totally denervated SGs. In this sense the SG is the gateway to understanding the health of peripheral autonomic nerves. PUBLIC HEALTHRELEVANCE: Existing tests lack sensitivity to detect peripheral nerve disease early when it is most susceptible to treatment. Neuro Devices, Inc. will show that it is feasible to construct a device that can detect early signs of neuropathy in cancer patients with chemotherapy-induced neuropathy by measuring abnormalities of sweat rate and sweat volume secreted by individual sweat glands.

Principal Investigator:

William R. Kennedy
612-625-1431
kenne001@umn.edu

Business Contact:

Daniel L. Kennedy
612-728-8080
kenne042@umn.edu
Small Business Information at Submission:

NEURO DEVICES, INC.
4103 E LAKE ST MINNEAPOLIS, MN 55406-

EIN/Tax ID: 127132145
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
REGENTS OF THE UNIVERSITY OF MINNESOTA
3003 SOUTH STATE STREET
1040 Wolverine Tower
ANN ARBOR, MI 48109-1274
Contact: