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Novel Catalytic MetalloDrug Targeting IRES RNA for Treatment of HCV Infection

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
R44AA016712
Solicitation Year:
2011
Solicitation Topic Code:
NIAAA
Solicitation Number:
PA09-095
Small Business Information
METALLOPHARM, LLC
1790 Riverstone Drive Delaware, OH -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2011
Title: Novel Catalytic MetalloDrug Targeting IRES RNA for Treatment of HCV Infection
Agency: HHS
Contract: 2R44AA016712-03A2
Award Amount: $2,004,496.00
 

Abstract:

DESCRIPTION (provided by applicant): HCV is responsible for 60% of the cases of chronic hepatitis and 50% of cases of cirrhosis, end- stage liver disease, and liver cancer. An effective vaccine has proved elusive and the preferred therapy with pegylated interferon is effective in less than 50% of patients with genotype 1 and 75% of patients with genotypes 2 or 3. Clearly, new treatment alternatives are needed. Interest in HCV IRES RNA as a drug target is reflected by the increasing number of small and largepharma companies pursuing that goal. MetalloPharm has created a novel platform technology (metallodrugs) that has the potential to irreversibly destroy the HCV IRES RNA. The specific aims are directed toward selection of a lead and back-up drug candidatefor IND-enabling pre- clinical testing following validation of cellular mode of action against IRES RNA and uptake mechanisms; assessment of PK, toxicity and efficacy data; and exploration of methods to improve serum half life. PUBLIC HEALTH RELEVANCE: Millions of people worldwide are infected with HCV, including a significant portion of the US population. HCV is responsible for 60% of the cases of chronic hepatitis and 50% of cases of cirrhosis, end-stage liver disease, and liver cancer. An effective vaccine has proved elusive and current therapy is effective in less than 50% of patients. Clearly, new treatment alternatives are needed. MetalloPharm has created a novel class of therapeutics (metallodrugs) that function by destroying a key molecule inthe viral life cycle with the potential to halt the progression of, or completely eliminate the virus.

Principal Investigator:

Ada S. Cowan
740-815-9851
metallopharm@gmail.com

Business Contact:

James A. Cowan
740-815-9851
metallopharm@gmail.com
Small Business Information at Submission:

METALLOPHARM, LLC
1790 Riverstone Drive Delaware, OH -

EIN/Tax ID: 114053584
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No