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TAS::75 0849::TAS TOPIC 255 DEVELOPMENT OF A TARGETED THERAPY FOR ACUTE MYELOID

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
N43CO110093
Solicitation Year:
2011
Solicitation Topic Code:
NCI
Solicitation Number:
Small Business Information
CLEVELAND LEUKEMIA THERAPEUTICS, LLC
11000 CEDAR AVE CLEVELAND, OH 44106-3069
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: TAS::75 0849::TAS TOPIC 255 DEVELOPMENT OF A TARGETED THERAPY FOR ACUTE MYELOID
Agency: HHS
Contract: N43CO110093
Award Amount: $199,833.00
 

Abstract:

Acute myeloid leukemia (AML) is one of the most common forms of leukemia in adults and despite advances in treatment the 5 year survival is less than 20-50% in adults and significantly lower in the elderly. The remarkable success in treating one relatively uncommon subset of AML, acute promyelocytic leukemia, with all trans-retinoic acid (ATRA) illustrates the great promise for agents with greater efficacy and less toxicity. Utilizing A TRA, the presumed cure of 75-85% of patients is possible. ATRA's remarkable success stems from the fact that AML is a disease characterized by the arrest of differentiation of immature myeloid cells. A TRA overcomes this block in differentiation by forcing leukemic cells to mature. Unfortunately A TRA does not work clinically for 90-95% of AML patients. We have identified a therapeutic target and an optimized lead compound against this target that leads to differentiation induction in AML patients that are not normally responsive to ATRA. In this application, we willtest the clinical utility of this novel agent for AML using mouse model systems. Provide key

Principal Investigator:

Mukesh Agarwal
216-789-6000
MUKESHAGARWAL@CLEVELANDLEUKTHER.COM

Business Contact:

Mukesh Agarwal
216-789-6000
MUKESHAGARWAL@CLEVELANDLEUKTHER.COM
Small Business Information at Submission:

CLEVELAND LEUKEMIA THERAPEUTICS LLC
11000 CEDAR AVE CLEVELAND, OH 44106-3069

EIN/Tax ID: 126292798
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No