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TAS::75 0893::TAS RAPID LARGE SCALE PRODUCTION OF PROTEIN THERAPEUTICS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
N43DA110015
Solicitation Year:
2011
Solicitation Topic Code:
NIDA
Solicitation Number:
Small Business Information
ANTAGEN PHARMACEUTICALS, INC.
650 ALBANY ST UNIT 112 BOSTON, MA 02118-2518
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: TAS::75 0893::TAS RAPID LARGE SCALE PRODUCTION OF PROTEIN THERAPEUTICS
Agency: HHS
Contract: N43DA110015
Award Amount: $150,000.00
 

Abstract:

AWith a long-term objective to efficiently manufacture protein therapeutics, the Contractor developed a mammalian expression vector pATG that incorporates human DNA regulatory elements to render long-term cell line stability, ensures the most stringent selection of high producers, and uses the strongest signal sequence for high level secretory expression without gene amplification. This system shortens mamallina cell line development from 1 year to 4-5 weeks. To make this system user-friendly, in this Phase I study, the Contractor will devise novel ways to further reduce cell line development time to 2 weeks; and demonstrate the robustness of its new system by comparing with commercially available vectors in manufacturing model proteins. The Contractor will provide contract CMO services for generating stable, high-producing CHO cells lines for large-scale production of recombinant antibodies and vaccines.

Principal Investigator:

Wenda Gao
617-826-9885
WENDAGAO01@GMAIL.COM

Business Contact:

Wenda Gao
617-826-9885
WENDAGAO01@GMAIL.COM
Small Business Information at Submission:

ANTAGEN PHARMACEUTICALS, INC.
650 ALBANY ST UNIT 112 BOSTON, MA 02118-2518

EIN/Tax ID: 999999999
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No