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RandD-OTHER R and D-B RES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
N43ES110008
Solicitation Year:
2011
Solicitation Topic Code:
NIEHS
Solicitation Number:
Small Business Information
Agiltron Corporation
15 Presidential Way Woburn, MA 01801-1040
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: RandD-OTHER R and D-B RES
Agency: HHS
Contract: N43ES110008
Award Amount: $147,753.00
 

Abstract:

Agiltron proposes to develop volumetric optical coherence microscopic imaging technology for the full anterior chamber of the rabbit eye with high depth resolution, high speed, and high sensitivity to quantitatively assess the depth and extent of initial injury (001) in ocular irritant test. Studies pioneered by Dr. Jester have provided strong evidence that 001 is an objective and universal biomarker to determine the severity of toxicity for various chemicals at time points much earlier than currently defined humane endpoints. The 4-0 (X, Y, Z, and t) optical coherence imaging proposed by Agiltron has the key properties in ultrahigh depth resolution, large depth range, and wide area coverage. In addition, the ultrahigh speed can effectively remove motion artifacts of living animals. Therefore the imaging technology provides the most appropriate tool to accurately evaluate the depth, area, and volume of the initial injury as well as the later responses in recovery. In particular, novel 3D registration and segmentation technology will be developed to enable the point-to-point comparison of the irritation progression and wound healing at the same tissue vicinity (XYZ dimensions) but different time points (t dimension) for quantitative, objective, and sensitive ocular safety assessments as well as the earlier human endpoints.

Principal Investigator:

Yueli Chen
781-935-1200
YCHEN@AGILTRON.COM

Business Contact:

Yueli Chen
781-935-1200
YCHEN@AGILTRON.COM
Small Business Information at Submission:

AGILTRON, INC.
15 Presidential Way Woburn, MA -

EIN/Tax ID: 104353958
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No