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TAS::75 0862::TAS 3D SKIN MODEL W/ENHANCED SENSIVITY and THROUGHPUT

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
N43ES110009
Solicitation Year:
2011
Solicitation Topic Code:
NIEHS
Solicitation Number:
Small Business Information
Stratatech Corporation
505 S. Rosa Road, Suite 169 Madison, WI -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: TAS::75 0862::TAS 3D SKIN MODEL W/ENHANCED SENSIVITY and THROUGHPUT
Agency: HHS
Contract: N43ES110009
Award Amount: $178,327.00
 

Abstract:

In vitro skin models have shown excellent potential for the evaluation of acute skin irritation. However, the current systems lack the ability to discriminate between mild and strong irritants and require labor-intensive protocols that limit test throughput. To address the three critical limitations of current in vitro dermal irritancy assays, we propose to 1) identify alternative endpoints to discriminate between strong and weak dermal irritants 2) develop a skin model more representative of the human in vivo environment and 3) format this assay to improve assay throughput. This Phase I SBIR feasibility study will begin by identifying alternative endpoints using Stratatech's full-thickness StrataTest human skin model to improve the prediction of irritancypotential. StrataTest is a fully-stratified, three-dimensional human skin model consisting of dermal and epidermal compartments, recapitulating the tissue architecture and barrier function of human interfollicular epidermis. Once improved endpoints have been identified, test performance will be evaluated using a small set of reference chemicals and compared to the current protocols. The resulting procedures will then be transitioned to a higher-throughput 96-well format full-thickness skin model. These advancements will address the key limitations of current in vitro irritancy tests to enable more rapid and predictive assessment of irritancy potential.

Principal Investigator:

Kathy Ramussen
608-441-2756
CRASMUSSEN@STRATATECHCORP.COM

Business Contact:

Kathy Ramussen
608-441-2756
CRASMUSSEN@STRATATECHCORP.COM
Small Business Information at Submission:

STRATATECH CORPORATION
510 CHARMANY DR STE 169 MADISON, WI 53719-1262

EIN/Tax ID: 392025292
DUNS: N/A
Number of Employees: N/A
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No