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SBIR PHASE 1 TOPIC 43

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
N43HB110034
Solicitation Year:
2011
Solicitation Topic Code:
NHLBI
Solicitation Number:
Small Business Information
APHIOS CORPORATION
3 E GILL ST WOBURN, MA 01801-1720
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: SBIR PHASE 1 TOPIC 43
Agency: HHS
Contract: N43HB110034
Award Amount: $149,440.00
 

Abstract:

The contractor will identify methodologies for broad spectrum inactivation of pathogens in red blood cell concentrates(RBCC). RBCCs are the main components of blood used in transfusion medicine, yet currently there are no FDAapproved methods for broad spectrum pathogen inactivation for RBCCs; instead, the risk of transfusion associatedpathogen transmission is reduced by screening the transfused blood for specific pathogens. Solvent-detergentmethod, currently approved by FDA for plasma, is active against only enveloped viruses and cannot be used forRBCCs since the RBCCs have a functional plasma membrane. The use of photodynamic compounds such aspsoralens and methylene blue in conjunction with UV light is approved for plasma and platelets in several Europeancountries but the lack of transparency of RBCCs to UV light can pose special challenges to successful and consistentpathogen inactivation in that system.

Principal Investigator:

Trevor Castor
781-932-6933
TCASTOR@APHIOS.COM

Business Contact:

Trevor Castor
781-932-6933
TCASTOR@APHIOS.COM
Small Business Information at Submission:

APHIOS CORPORATION
3 E GILL ST WOBURN, MA 01801-1720

EIN/Tax ID: 104320532
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No