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Development of a simple killed enterotoxigenic E. coli vaccine for weaned pigs

Award Information

Agency:
Department of Agriculture
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
2011-00448
Solicitation Year:
2011
Solicitation Topic Code:
8.3
Solicitation Number:
Small Business Information
BROOKINGS BIOMEDICAL
4108 WILLOW LN Brookings, SD 57006-7020
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: Development of a simple killed enterotoxigenic E. coli vaccine for weaned pigs
Agency: USDA
Contract: 2011-00448
Award Amount: $100,000.00
 

Abstract:

Enterotoxigenic Escherictia coli causes diarrhea (E. coli scours) in young weaned pigs. There currently are no licensed killed vaccines for the disease, and the available living vaccines do not express toxins which should be a major target of a vaccine. This lack of toxin antigens may affect how well the vaccines protect pigs. We have recently developed an experimental killed vaccine for pig strains of E. coli that completely protects the animals from K88+ E. coli. However, the product would be too cumbersome to mass manufacture and to expensive to use in commercial swine production. The purpose of this current project is to utilize the knowledge gained from developing the experimental vaccine to create a simpler and less expensive product that would have commercial value, and to test that product for safety, potency and effectiveness in protecting weaned pigs from experimental challenge with highly virulent K88+ enterotoxigenic E. coli.

Principal Investigator:

Mojun Zhao
Senior Scientist
478-320-0614
zhaomojun@gmail.com

Business Contact:

David H. Francis
President
605-692-6912
francis@brookings.net
Small Business Information at Submission:

BROOKINGS BIOMEDICAL
4108 WILLOW LN Brookings, SD 57006-7020

EIN/Tax ID: 204797897
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No