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High-capacity and Cost-effective Manufacture of Chloroperoxidase

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
Program Year/Program:
2011 / STTR
Agency Tracking Number:
A11A-014-0054
Solicitation Year:
2011
Solicitation Topic Code:
A11a-T014
Solicitation Number:
2011.A
Small Business Information
Infoscitex Corporation
303 Bear Hill Road Waltham, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: High-capacity and Cost-effective Manufacture of Chloroperoxidase
Agency / Branch: DOD / ARMY
Contract: W911NF-11-C-0237
Award Amount: $99,889.00
 

Abstract:

The low cost chloroperoxidase can be potentially applicable to the inactivation of chemical agents due to its exceptional stability, broad substrate profile, and high catalytic efficiency. However, the high cost of producing large amounts of CPO is a major obstacle precluding the formulation and field deployment of this enzyme for chemical agent decontamination. Infoscitex Corporation (IST) and University of Massachusetts at Lowell (UML) propose a technology for high yield commercial production of CPO by an improved strain of filamentous fungus Caldariomyces fumago. The high yields of the enzyme production by C. fumago will be achieved via an advanced method of strain improvement by its directed evolution for target resistance established at Infoscitex. The high activity and stability of the resultant product will be assured by use of the most advanced technology for CPO isolation and purification. The new CPO producing strain will be coupled with state of the art protein production and purification capacity to achieve the required kilogram-scale manufacturing capabilities.

Principal Investigator:

Vladimir Gilman
Principal Scientist
(781) 890-1338
vgilman@infoscitex.com

Business Contact:

Andrea Hicks
Senior Contract Administrator
(937) 429-9008
ahicks@infoscitex.com
Small Business Information at Submission:

Infoscitex Corporation
303 Bear Hill Road Waltham, MA -

EIN/Tax ID: 043537120
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
University of Massachusetts
One University Ave
Lowell, MA 01854-
Contact: Linda Concino
Contact Phone: (978) 934-4723