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Nanoparticle Technology for Minimally-invasive Delivery of DNA Vaccines

Award Information

Department of Defense
Award ID:
Program Year/Program:
2011 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
12734 Cimarron Path San Antonio, TX 78249-3424
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2011
Title: Nanoparticle Technology for Minimally-invasive Delivery of DNA Vaccines
Agency / Branch: DOD / ARMY
Contract: W81XWH-11-C-0512
Award Amount: $99,999.00


Venezuelan equine encephalitis virus causes an acute debilitating disease in humans characterized by fever, mylagia, headache, lymphopenia and malaise and can also lead to neurological symptoms and encephalitis. The highly pathogenic strains are frequently associated with epidemics in North Central and South America and VEEV is classified as a category B select agent. Vaccines against VEEV have been elusive in that live attenuated vaccines produce life long immunity in some and no detectable immune response or adverse effects in others. Inactivated virus fails to protect against aerosol challenge. A DNA vaccine under intensive testing in different formulations and routes of delivery has had promising but incomplete success. Particle mediated epidermal delivery (PMED) of the vaccine is the most promising yet but has not protected all subjects. We propose a method for delivery of the existing DNA vaccine using a controlled release nanoparticle that provides a continual boosting effect through increased levels of antigen uptake and presentation. Controlled release particles developed in our labs have dramatically enhanced efficacy of safe but poorly performing vaccines. We propose a nanoparticle delivery platform to improve efficacy of the VEEV DNA vaccine and permit ease of delivery through PMED or intranasal administration.

Principal Investigator:

Allison C. Rice-Ficht
Regents Professor and CMDD Director
(979) 458-1024

Business Contact:

James V. Janowiak
(210) 877-0111
Small Business Information at Submission:

NanoRelease Technologies, Inc.
12734 Cimarron Path San Antonio, TX 78249-3424

EIN/Tax ID: 202294362
Number of Employees:
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
Texas A&M Research Foundation
400 Harvey Mitchell Pkwy S.
Suite 100
College Station, TX 77843-1114
Contact: Ruth Manning
Contact Phone: (979) 845-8616