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Specific Epigenetic Molecules Involved in Wound Healing and Repair

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
Program Year/Program:
2011 / STTR
Agency Tracking Number:
A11A-030-0459
Solicitation Year:
2011
Solicitation Topic Code:
A11a-T030
Solicitation Number:
2011.A
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: Specific Epigenetic Molecules Involved in Wound Healing and Repair
Agency / Branch: DOD / ARMY
Contract: W81XWH-11-C-0480
Award Amount: $99,999.00
 

Abstract:

The ability to direct the wound pathways following injury could provide a critical path in wound care at crucial times during the progression of healing. A promising field of study in wound healing is epigenetics; alterations in gene expression caused by mechanisms other than changes in DNA sequence. Identification of epigenetic factors and their manipulation may result in the development of novel therapies that enhance wound recovery as well as diagnostic tests that assess the progress of wound repair. In this Phase I, Agave BioSystems, in collaboration with Dr. Vincenzo Pirrotta of Rutgers University, proposes to characterize the role of Polycomb Group (PcG) complexes during the wound healing process and manipulate PcG repression to accelerate wound healing. PcG complexes are known to regulate multiple genes involved in keratinocyte differentiation and proliferation during wound healing. We anticipate that PcG repression may have different effects at different stages in the healing process. While derepression might be advantageous to express genes that promote healing, it is known that PcG repression of other genes is required for cell proliferation that is also essential for wound healing. Therefore, the specific PcG targets and timing of PcG derepression are important and may require a two-stage treatment.

Principal Investigator:

Kathie Berghorn
Staff Scientist
(607) 272-0002
kberghorn@agavebio.com

Business Contact:

Noe Salazar
President
(512) 373-8601
nsalazar@agavebio.com
Small Business Information at Submission:

Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -

EIN/Tax ID: 161551819
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes
Research Institution Information:
Rutgers University
Office of Research and Sponsor
675 Hoes Lane, Rm. R109
Piscataway, NJ 08854-5635
Contact: Diane Ambrose
Contact Phone: (732) 418-8464