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Design Automation Software for DNA-Based Nano-Sensor Architectures

Award Information

Department of Defense
Office of the Secretary of Defense
Award ID:
Program Year/Program:
2011 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Celadon Laboratories, Inc.
6525 Belcrest Rd Suite 521 Hyattsville, MD -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2011
Title: Design Automation Software for DNA-Based Nano-Sensor Architectures
Agency / Branch: DOD / OSD
Contract: W911NF-11-C-0082
Award Amount: $100,000.00


A continuing and growing threat to U.S. military personnel and civilians is exposure to toxic chemicals and pathogens. Useful detection systems exist, but it remains imperative to investigate next-generation technologies that have the potential to improve by an order of magnitude the cost, sensitivity and size of sensor devices. A promising technology that may achieve these goals is DNA-based nano-sensors. In order for DNA-based nano-sensors to become commercially viable, the technology needs automated assay design software. Towards this end, Celadon will partner with Dr. David H. Mathews, one of the few internationally recognized experts in the computation of nucleic acid structures. During Phase I, the Celadon/Mathews team will compute databases of optimal helices and loops; develop a heuristic algorithm so as to obviate the need to evaluate an entire, computationally intractable, structure; develop a new algorithm for design of pseudo-knots; develop draft versions of Product Requirements, Software Development and Validation Project Plan, Design Specifications, and Technical Specifications; and demonstrate proof-of-concept design software.

Principal Investigator:

Raymond J. Peterson
Chief Science Officer
(301) 683-2118

Business Contact:

Lawrence Kessner
Chief Executive Officer
(301) 683-2117
Small Business Information at Submission:

Celadon Laboratories, Inc.
6525 Belcrest Rd Suite 521 Hyattsville, MD 20782-2003

EIN/Tax ID: 522223222
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: Yes
Research Institution Information:
University of Rochester
518 Hylan Building
P.O. Box 270140
Rochester, NY 14627-0140
Contact: Tammie Martin
Contact Phone: (585) 275-4031