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Design Software for DNA-Based Sensing Nano-Architectures

Award Information

Agency:
Department of Defense
Branch:
Office of the Secretary of Defense
Award ID:
Program Year/Program:
2011 / STTR
Agency Tracking Number:
O10B-003-2002
Solicitation Year:
2010
Solicitation Topic Code:
OSD10-T003
Solicitation Number:
2010.B
Small Business Information
Parabon NanoLabs, Inc.
11260 Roger Bacon Drive Suite 406 Reston, VA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: Design Software for DNA-Based Sensing Nano-Architectures
Agency / Branch: DOD / OSD
Contract: W911NF-11-C-0076
Award Amount: $100,000.00
 

Abstract:

Beginning from an advanced stage of development, this Phase I SBIR project will produce design automation software for creating DNA nanostructures for a wide variety of applications, remedying a deficit that has stymied advancement in this promising field. Building atop an established grid computing platform, the software will combine a robust, easy-to-use, CAD (computer-aided design) interface, which allows for the specification of complex DNA-based nano-sensor architectures, with a grid-powered sequence optimization engine that computes the sequence-sets required for reliable self-assembly of specified designs. The research plan calls for the integration of a nearest neighbor thermodynamics model with an opportunistic evolutionary search algorithm to effect sequence optimization across a large-scale computational grid. These new capabilities will reduce defects and increase the manufacturing yield of designed nanostructures, and provide designers with novel control over the order of DNA self-assembly, which in turn will lead to products with enhanced functionality. To test the resultant software, a prototype nano-scale molecular capture system will be designed and its formation experimentally validated in Phase I. A capture and reporter bio-sensor system will be developed and demonstrated in Phase II.

Principal Investigator:

Steven Armentrout
President
(703) 689-9689
steve@parabon.com

Business Contact:

Paula Gawthorp-Armentrout
Corporate Officer
(703) 689-9689
parmentrout@parabon.com
Small Business Information at Submission:

Parabon NanoLabs, Inc.
11260 Roger Bacon Drive Suite 406 Reston, VA -

EIN/Tax ID: 262194625
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
Marshall University Research Corp
401 11th Street
Suite 1400
Huntington, WV 25701-2225
Contact: Janice Morgan
Contact Phone: (304) 696-2468