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Design Automation Software for DNA-Based Nano-Sensor Architectures

Award Information

Department of Defense
Office of the Secretary of Defense
Award ID:
Program Year/Program:
2011 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Firebird Biomolecular Sciences
13709 Progress Blvd  N 104 Alachula, FL 32615-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2011
Title: Design Automation Software for DNA-Based Nano-Sensor Architectures
Agency / Branch: DOD / OSD
Contract: W911NF-11-C-0086
Award Amount: $100,000.00


Because of chemical behaviors of real DNA molecules, the nanotechnology envisioned by the Defense Department in this Solicitation will be possible only if design automation software creates nanostructures that exploit artificially expanded genetic information systems (AEGIS). AEGIS DNA molecules have more than the four nucleotides (GACT) found in natural DNA. Our software will accommodate nanoarchitectures built from these four, plus eight additional orthogonally pairing AEGIS nucleotides. By evading the computational challenges associated with natural DNA nanostructures, AEGIS will allow delivery at the end of Phase I, ahead of schedule, software that helps nanotechnologists design nanostructures that incorporate binding and catalytic DNA molecules, sensing functionality, and optical signaling elements. Additional benefits of AEGIS DNA nanostructures are their enhanced stability and potential to support continuous environmental monitoring. Also ahead of schedule, our Phase I work will deliver a physical example of a nanostructure containing these functional elements. This will allow Phase II to focus on higher level nanostructure performance, including dynamic architectures, interfaces to electrical output, and amorphous computing. This project overlaps Firebird's business, which supports human diagnostics based on reagent innovations like AEGIS. Adding nanotechnology to its existing business makes commercial sense, and will help"dual uses"emerge from this project.

Principal Investigator:

Steven Benner
(352) 271-7005

Business Contact:

Romaine Hughes
(352) 271-7005
Small Business Information at Submission:

Firebird Biomolecular Sciences, LLC
13709 Progress Boulevard Box 17 Alachua, FL -

EIN/Tax ID: 900355722
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
University of Rochester
518 Hylan Building
P.O. Box 270140
Rochester, NY 14627-0140
Contact: Tammie Martin
Contact Phone: (585) 275-4031