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Development of monoclonal catalytic antibodies for HIV immunotherapy

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2010 / STTR
Agency Tracking Number:
R41AI087527
Solicitation Year:
2010
Solicitation Topic Code:
NIAID
Solicitation Number:
PA09-081
Small Business Information
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: Development of monoclonal catalytic antibodies for HIV immunotherapy
Agency: HHS
Contract: 1R41AI087527-01
Award Amount: $173,142.00
 

Abstract:

DESCRIPTION (provided by applicant): We have raised murine monoclonal antibodies (MAbs) to a conserved region of the CD4 binding site of gp120 (CD4bs) that neutralize genetically diverse HIV strains. The MAbs have a novel mechanism of action. They hydrolyze multiple molecules of gp120, thereby imparting MAb increased biological efficacy. About 10% of HIV infected subjects develop resistance to currently available drug regimens and have no other treatment options. Our MAbs are intended to fulfill this unmetmedical need. In the present Phase I proposal, we will conduct molecular engineering and initial functional studies necessary to preparing therapy-grade MAbs. We will: (a) clone two chimeric MAbs (cMAbs) with reduced immunogenicity by fusing the murine catalytic variable domains to human IgG constant domains; (b) establish that the cMAbs express catalytic and epitope specificity properties comparable to the parent MAbs; (c) determine the potency with which the cMAbs neutralize genetically diverse HIV strains as the initial efficacy indicator; and (d) confirm the absence of cMAb cross-reaction with host human proteins, a requirement for a MAb designed for clinical use in humans. If the cMAbs meet the Phase I milestones, we will seek Phase II support for animal model efficacy tests, toxicity analysis and pharmacokinetic studies to enable human testing. PUBLIC HEALTH RELEVANCE: No adequate therapies are available for HIV infected patients who develop resistance to antiretroviral drugs. We will examine thefeasibility of developing antibodies that degrade the coat protein of HIV for treatment of such patients.

Principal Investigator:

Stephanie A. Planque
713-270-5391
stephanie.a.planque@uth.tmc.edu

Business Contact:

Benjamin A. Adler
713-270-5391
benjamin.adler@mac.com
Small Business Information at Submission:

COVALENT IMMUNOLOGY PRODUCTS, INC.
MISSOURI CITY, TX 77459-

EIN/Tax ID: 126426956
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
University Of Texas Hlth Sci Ctr Houston
Box 20036
HOUSTON, TX 77225-
Contact: