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In Vivo Expansion of Human Hepatocytes in FRG Mice

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / STTR
Agency Tracking Number:
R42RR028190
Solicitation Year:
2011
Solicitation Topic Code:
NCRR
Solicitation Number:
N/A
Small Business Information
YECURIS CORPORATION
3181 SW SAM JACKSON PARK RD, L321 PORTLAND, OR 97239-3098
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2011
Title: In Vivo Expansion of Human Hepatocytes in FRG Mice
Agency: HHS
Contract: 2R42RR028190-02
Award Amount: $773,666.00
 

Abstract:

DESCRIPTION (provided by applicant): The FDA requires the use of human hepatocytes for preclinical drug testing by pharmaceutical researchers, but unfortunately the supply of these cells is severely limited. Currently, cadaveric donors and surgical liver resection specimens are currently the only available source of human hepatocytes. These samples are very scarce and often yield cells of poor quality unsuitable for research. We have developed technology to massively expand fully functional primary human hepatocytes by serial transplantation in immune deficient FRGN mice in vivo. Hepatocytes isolated from these animals are highly viable and functional. Cell farming in FRGN mice allows the production of an unlimited supply of human hepatocytes for research in toxicology, drug metabolism, infectious disease, and cancer biology. The aims of this application are to optimize the isolation and storage of farmed hepatocytes and to fully validate their utility in comparison to the currently available cells. Once fully validated, these cells are going to be valuable in the commercial market. PUBLIC HEALTH RELEVANCE: The successful implementation of human hepatocyte farming technology will significantly impact human health by providing this vital resource for drug development at a higher quality and lower cost than is currently available.

Principal Investigator:

Markus Grompe
(503) 494-6888
grompem@ohsu.edu

Business Contact:

John Bial
(503) 494-9597
johnbial@yecuris.com
Small Business Information at Submission:

YECURIS CORPORATION
3181 SW SAM JACKSON PARK RD, L321 PORTLAND, OR 97239-3098

EIN/Tax ID: 120895423
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No