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Biomimetics for treating biofilm-embedded infections

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
Program Year/Program:
2010 / STTR
Agency Tracking Number:
A2-4098
Solicitation Year:
2009
Solicitation Topic Code:
A09A-T004
Solicitation Number:
2009.A
Small Business Information
PolyMedix, Inc.
170 N. Radnor-Chester Road RADNOR, PA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2010
Title: Biomimetics for treating biofilm-embedded infections
Agency / Branch: DOD / ARMY
Contract: W911NF-10-C-0111
Award Amount: $749,860.00
 

Abstract:

Multi-drug resistant (MDR) biofilms are one of the most difficult bacterial infections to treat. Current antibiotics are increasingly unable to cure these infections; underscoring the need to develop new antibiotics that operate through novel mechanisms which overcome the biofilm environment. PolyMedix has discovered a novel class of antibiotics, SMAMPS (small mimics of antimicrobial peptides), that work through a mechanism which appears to evade resistance development and is not depended on bacterial growth. One SMAMP is currently in human clinical trials to treat nosocomial infections, including methicillin-resistant S. aureus. During the Phase I STTR, potently active lead compounds were identified against pathogens associated with biofilm-embedded infections. Resistance to other antibiotics did not influence susceptibility to the PMX mimetics. Rapid killing kinetics and a low risk for the development of resistance are hallmark features of PMX mimetics and underscore their potential as novel antimicrobial agents suitable for further development for treatment of infections complicated by biofilm formation. This Phase II STTR aims to identify SMAMPs that are potently active in in vitro and in vivo biofilm infection models and possess pharmaceutical qualities suitable for further development.

Principal Investigator:

Richard W. Scott
VP Research
(484) 598-2336
rscott@polymedix.com

Business Contact:

Dawn Eringis
Director, Scientific Affairs
(484) 598-2334
deringis@polymedix.com
Small Business Information at Submission:

PolyMedix, Inc.
170 N. Radnor-Chester Road Suite 300 Radnor, PA 19087-5279

EIN/Tax ID: 270125925
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
University of Massachusetts Amherst
Office of Grants and Contract
70 Butterfield Terrace
Amherst, MA 01003-9242
Contact: Carol Sprague
Contact Phone: (413) 545-0698