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TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
N44DA110023
Solicitation Year:
2011
Solicitation Topic Code:
NIDA
Solicitation Number:
Small Business Information
SILOAM BIOSCIENCES
413 Northland Blvd CINCINNATI, OH 45240
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2011
Title: TAS::75 0893::TAS RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE RATIO, SILOAM BIOSCIENCES, INC. CINCINNATI, OH
Agency: HHS
Contract: N44DA110023
Award Amount: $997,254.00
 

Abstract:

Recent clinical research has established that this ratio is indicative of the activity of the CYP2A6 enzyme that metabolises nicotine. Nicotine is metabolized to COT and then to 3HC. People with high activity of this enzyme, clear nicotine faster and henceneed more nicotine to maintain the addiction. To-date the 3HC/COT ratio could only be determined by specialized measurement techniques such as Liquid-Chromatography/Mass Spectrometry. Although accurate, these tests are expensive and take 2-5 days to deliver results. Smoking is the leading cause of cancer related deaths, and is attributable cause for almost 400,000 deaths per year in the US> The POCT for nicotine metabolites can help in increasing smoking cessation rates and directly contribute to reduced mortality/healthcare burden.

Principal Investigator:

Aniruddha Puntambekar
513-429-2976
ANIRUDDHA@SILOAMBIO.COM

Business Contact:

Aniruddha Puntambekar
513-429-2976
ANIRUDDHA@SILOAMBIO.COM
Small Business Information at Submission:

SILOAM BIOSCIENCES, INC.
413 NORTHLAND BLVD CINCINNATI, OH 45219-2333

EIN/Tax ID: 200329437
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No