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Artificial Tissue Matrices for Bone Repair

Award Information

Department of Defense
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
MO-SCI Corp.
4040 Hy Point North Rolla, MO 65401-8277
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2011
Title: Artificial Tissue Matrices for Bone Repair
Agency: DOD
Contract: N00014-11-M-0113
Award Amount: $70,000.00


This Small Business Innovation Research (SBIR) by Mo-Sci Corporation in collaboration with the Indiana University School of Dentistry (IU) and the Missouri University of Science & Technology (Missouri S & T) proposes to use bioactive glass bone scaffolds for bone repair. The objective is to develop a completely artificial bone substitute material that mimics human bone and can replace long bones, facial bones and skull bones. The new bioactive glass scaffolds are biodegradable and biocompatible and are synergistic with the natural bone tissue regeneration process. The scaffolds are manufactured by selective laser sintering (SLS), to mimic the structure and mechanical properties of normal healthy trabecular bone tissue, and with good capability for vascularization. The bioactive glass scaffolds will be tested if can function as carrier for Bone Morphogenic Protein-2 (BMP-2) and induce bone healing in small animals in Phase I. Mo-Sci Corp. will develop the SLS scaffolds as Intellectual Property, then work with the American Medical Association and the Food and Drug Administration (FDA) to gain the necessary approvals to begin making the SLS bone scaffolds available to greater medical community.

Principal Investigator:

Mariano Velez
R&D Senior Engineer
(573) 364-2338

Business Contact:

Thomas Day
(573) 364-2338
Small Business Information at Submission:

MO-SCI Corporation
4040 Hypoint North Rolla, MO -

EIN/Tax ID: 431372193
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No