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Universal Bio-Sample Preparation Module

Award Information

Department of Defense
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Physical Optics Corporation
Electro-Optics Systems Division 1845 West 205th Street Torrance, CA 90501-1510
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2011
Title: Universal Bio-Sample Preparation Module
Agency: DOD
Contract: W911NF-11-C-0062
Award Amount: $69,994.00


To address the U.S. Army"s need for a technology platform for automated, universal sample preparation for biosensor systems using small volumes of samples from complex matrices, Physical Optics Corporation (POC) proposes to develop a universal bio-sample preparation (UniBioPrep) technology, based on the combination of size-exclusion cleansing and an electrodeless dielectrophoretic (DEP) continuous-flow bio-agents separation technique followed by bio-agent purification, elution, and collection. The innovations in the UniBioPrep module will enable the module to perform biological target separation from low volumes of various complex matrices, purification, desalting if needed, concentration, and collection automatically, without use of specific reagents, and in only 5 minutes. In Phase I, POC will demonstrate the feasibility of the UniBioPrep module by developing a benchtop prototype capable of separating and collecting individual classes of biological targets from a mixture in buffer in less than 15 minutes. In Phase II, POC plans to further develop, refine, and validate the UniBioPrep module, into a module capable of separating the biological targets from complex matrices such as homogenized food, soil, or aqueous sample from an aerosol collector within 5 minutes with the required purity.

Principal Investigator:

Gregory Zeltser
Principal Scientist
(310) 320-3088

Business Contact:

Gordon Drew
Chief Financial Officer
(310) 320-3088
Small Business Information at Submission:

Physical Optics Corporation
Photonic Systems Division 20600 Gramercy Place, Bldg. 100 Torrance, CA -

EIN/Tax ID: 330118051
Number of Employees:
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No