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Novel Toxicity Sensor using Genetically Engineered, Permeabilized, Freeze-Dried…

Award Information

Department of Defense
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
401 E STATE ST STE 200 ITHACA, NY 14850-4400
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2011
Title: Novel Toxicity Sensor using Genetically Engineered, Permeabilized, Freeze-Dried Bacteria
Agency: DOD
Contract: W81XWH-11-C-0039
Award Amount: $70,000.00


Field testing of water samples is needed for broad and sensitive detection of toxic industrial chemicals, or TICs. The use of unicellular organisms in cell-based detection systems is particularly advantageous both because these organisms have developed a natural ability to respond to environmental changes, and because several methods for long-term storage with minimal maintenance requirements have been established and tested. Long-term storage of packaged freeze-dried cells with no need for significant environmental controls such as temperature eliminates limitations in the development of a rugged field-deployable device perfectly adapted to logistical requirements in a military setting. The need for a toxicant of interest to cross the natural barriers such as cell walls or membranes is perhaps the only significant limitation to the detection capability of any cell-based system. This will be addressed as part of the proposed effort by testing known genetic and biochemical approaches to the permeabilization of the bacterial cell wall to develop novel biosensors with broader and more sensitive detection capabilities.

Principal Investigator:

Julien Fey
Senior Scientist
(607) 272-0002

Business Contact:

Noe Salazar
(512) 656-6200
Small Business Information at Submission:

Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -

EIN/Tax ID: 161551819
Number of Employees:
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No