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Software Tool for Complex Biomarker Discovery

Award Information

Agency:
Department of Defense
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
A103-159-0136
Solicitation Year:
2010
Solicitation Topic Code:
A10-159
Solicitation Number:
2010.3
Small Business Information
IFXworks LLC
2915 COLUMBIA PIKE ARLINGTON, VA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: Software Tool for Complex Biomarker Discovery
Agency: DOD
Contract: W81XWH-11-C-0036
Award Amount: $66,000.00
 

Abstract:

We propose development of a feature discovery algorithm for identification of multivariate (or composition) biomarker signatures from high-dimensional omics data. The proposed algorithm operates on sets of heterogeneous features and returns a selected subset of significant features and a continuous quantitative metric that is indicative of a particular state of the data (i.e. presence or absence of a toxic hazard). There is no requirement that all features analyzed be of the same type; therefore, the algorithm allows for input of a mixture of data types. The types of data suitable for analysis may be gene expression values, gene copy numbers, presence of particular mutations or SNPs, or methylation patterns. Initially this algorithm was formulated for mining for complex biomarkers in oncology, and is extended here for the purpose of continuous monitoring of environmental and chemical hazards.

Principal Investigator:

Xianfeng Chen
Partner, CSO
(202) 552-8326
vm@ifxworks.com

Business Contact:

Vladimir Makarov
Partner
(202) 552-8326
vm@ifxworks.com
Small Business Information at Submission:

IFXworks LLC
21100 Dulles Town Cir, Suite 256 Dulles, VA -

EIN/Tax ID: 263269846
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No