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Controlled Release of Topical Nitric Oxide for Treating Cutaneous Injuries

Award Information

Agency:
Department of Defense
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
A103-160-0345
Solicitation Year:
2010
Solicitation Topic Code:
A10-160
Solicitation Number:
2010.3
Small Business Information
Zeomedix
26 Ashlawn Circle Malvern, PA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: Controlled Release of Topical Nitric Oxide for Treating Cutaneous Injuries
Agency: DOD
Contract: W81XWH-11-C-0031
Award Amount: $70,000.00
 

Abstract:

In this proposal Zeomedix proposes to develop a dressing for acute trauma wounds based on its alginate/zeolite encapsulating nitric oxide (NO) technology. Nitric oxide has been shown to enhance the wound healing process as well as act as a powerful antibacterial agent. However, delivery of nitric oxide to a wound area is extremely challenging because NO is a gas. Zeomedix"s approach is to use zeolites that bind NO molecules when exposed to a stream of gaseous NO. When NO-loaded zeolites come in contact with water (or wound fluid), NO is released into the wound area. The aims of this project are to (1) develop a wound dressing that achieve a rapid initial burst of NO for antimicrobial effect followed by a slow extended release of NO for up to 24 hours to accelerate wound closure; (2) demonstrate the stability of a NO-zeolite based wound dressing over a period of up to 4 months; and (3) to demonstrate the antimicrobial effectiveness of a NO-zeolite based wound dressing.

Principal Investigator:

John C. Aybar
CEO
(610) 517-7818
aybarc@gmail.com

Business Contact:

John C. Aybar
CEO
(610) 517-7818
aybarc@gmail.com
Small Business Information at Submission:

Zeomedix, LLC
26 Ashlawn Circle Malvern, PA -

EIN/Tax ID: 264745889
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No