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A Novel Microfludic Device for Drug Toxicity Studies

Award Information

Agency:
Department of Defense
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
C2-0337
Solicitation Year:
2011
Solicitation Topic Code:
CBD10-103
Solicitation Number:
2011.1
Small Business Information
CFD Research Corporation
215 Wynn Dr., 5th Floor Suite D Huntsville, AL 35805-
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2011
Title: A Novel Microfludic Device for Drug Toxicity Studies
Agency: DOD
Contract: HDTRA1-11-C-0044
Award Amount: $749,933.00
 

Abstract:

Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological conditions (morphology, flow and cellular make-up) of organs for quantitative prediction of in vivo toxicity of the drug candidates. While accelerating the drug screening process, this device also offers the promise of reducing animal trials. During Phase I, we demonstrated technology proof-of-principle using liver cells (hepatocytes) as a model for toxicity analysis. Effect of drug permeation, concentration and time dependent toxicity under perfusion and diffusion based conditions was highlighted. Finally, co-culture of vascular and tissue cells mimicking the in vivo conditions were demonstrated. Phase II will expand the platform to include cells from other organs of interest namely brain and kidney. Systems biology approaches will be used to identify biomarkers of toxicity. Whole body concept will be developed to predict metabolized drug induced toxicity on different organs. Finally, framework for a high-throughput drug toxicity assay system will be developed.

Principal Investigator:

Balabhaskar Prabhakarpandian
Principal Scientist
(256) 327-0665
tsb@cfdrc.com

Business Contact:

Deborah Phipps
Senior Contracts Speciali
(256) 726-4884
dap@cfdrc.com
Small Business Information at Submission:

CFD Research Corporation
215 Wynn Dr., 5th Floor Huntsville, AL -

EIN/Tax ID: 630944385
DUNS: N/A
Number of Employees:
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No