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Rickettsiae Detection Dipstick

Award Information

Department of Defense
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Physical Optics Corporation
Electro-Optics Systems Division 1845 West 205th Street Torrance, CA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2011
Title: Rickettsiae Detection Dipstick
Agency: DOD
Contract: W81XWH-10-C-0011
Award Amount: $779,988.00


To address the U.S. Army need for a hand-held, field-usable assay capable of diagnosing rickettsial disease in sick soldiers to aid early treatment with the appropriate antibiotic, Physical Optics Corporation (POC) proposes to complete the development of a new Rickettsiae Detection Dipstick (RDD). The RDD is a hand-held device based on a combination of lateral-flow immunochromatography technology and lab-on-chip principles. The RDD assay will rapidly (10 min) distinguish rickettsia antigens/pathogens in the spotted fever group (SFG) from typhus group (TG) in a blood sample. The RDD will be inexpensive, portable, and easy to use in a one-step protocol with at least 85% of the sensitivity and 85% of the specificity of current gold-standard assays. The device will use heat-stable reagents, have no special storage requirements, and require no power to operate. In Phase I POC demonstrated the feasibility of the RDD device by fabricating a prototype and demonstrating its capability to identify and differentiate inactivated rickettsia from SFG and TG spiked into porcine blood at concentrations

Principal Investigator:

Gregory Zeltser
Principal Scientist
(310) 320-3088

Business Contact:

Gordon Drew
Chief Financial Officer
(310) 320-3088
Small Business Information at Submission:

Physical Optics Corporation
Applied Technologies Division 20600 Gramercy Place, Bldg. 100 Torrance, CA -

EIN/Tax ID: 330118051
Number of Employees:
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No