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Non-invasive Continuous Hemodynamic Monitor

Award Information

Department of Defense
Defense Advanced Research Projects Agency
Award ID:
Program Year/Program:
2012 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
44 HUNT ST WATERTOWN, MA 02472-4699
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2012
Title: Non-invasive Continuous Hemodynamic Monitor
Agency / Branch: DOD / DARPA
Contract: W31P4Q-12-C-0192
Award Amount: $99,997.00


Emergency departments, trauma centers, and military field physicians have a critical need for a simple, easy-to-use, and reliable method of monitoring the onset of hemorrhagic shock that is able to predict onset during the compensatory phase, before syncope and cardiac collapse signaled by a rapid drop in blood pressure. In collaboration with Dr. Michael Joyner"s laboratory at the Mayo Clinic, RMD is developing a near infrared capillary blood flow measurement system (CapFlowTM), based upon diffuse correlation spectroscopy (DCS), that will predict shock onset. In its final configuration this will be a small innocuous patch that wirelessly communicates with a remote station and noninvasively monitors physiological status, assessing soldier health either in the field or in an emergency/ triage setting. Using the lower body negative pressure model in humans in Phase I we will: 1. provide proof-of-principle of the value of using DCS blood flow measurement as a shock predictor; 2. determine the depth beneath the skin where blood flow correlates most strongly with cardiac output; and 3. determine the"best"site for attaching the DCS probe to the skin.

Principal Investigator:

David Wolf
Group Leader, Optics and Photonics
(617) 668-6800

Business Contact:

Joanne N. Gladstone
Vice President
(617) 668-6800
Small Business Information at Submission:

Radiation Monitoring Devices, Inc.
44 Hunt Street Watertown, MA -

EIN/Tax ID: 262897516
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
Mayo Clinic
200 First Street SW
Rochester, MN 55905-
Contact: Michael J. Joyner, M.D.
Contact Phone: (507) 255-7197