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Design Software for DNA-Based Sensing Nano-Architectures

Award Information

Department of Defense
Office of the Secretary of Defense
Award ID:
Program Year/Program:
2012 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Parabon NanoLabs, Inc.
11260 Roger Bacon Drive Suite 406 Reston, VA 20190-5203
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2012
Title: Design Software for DNA-Based Sensing Nano-Architectures
Agency / Branch: DOD / OSD
Contract: W911NF-12-C-0061
Award Amount: $750,000.00


Building on an existing grid computing platform and DNA origami design automation software that leverages such, this Phase II STTR project will produce a CAD (computer-aided design) application for designing DNA nanostructures for a variety of applications. The application, called inSequio, addresses multiple deficits that have blocked advancement in this promising field. It combines an easy-to-use interface, which allows for the specification of complex DNA-based nano-sensor architectures, with an optimization engine that computes the sequence-sets required for reliable self-assembly of specified designs. Among the many enhancements planned for Phase II, we will (1) augment inSequio"s thermodynamics model to support artificial DNA bases; (2) add a reduced model nanoscale dynamics simulator that enables global dynamics calculations; and (3) add a"region of interest"atomistic simulator for active components of the design, which will provide spectroscopic predictions related to optoelectronic sensing, particularly in the THz domain. These new capabilities will provide designers with novel insight into structure functionality during the design process. The project will conclude with a ready-to-use (TRL 9) software application. To demonstrate the utility of the resultant software, a prototype nano-scale molecular sensor for Ricin, composed of dynamic capture and reporting moieties, will be designed, developed and demonstrated.

Principal Investigator:

Steven Armentrout
(703) 689-9689

Business Contact:

Corporate Secretary
(703) 689-9689
Small Business Information at Submission:

Parabon NanoLabs, Inc.
11260 Roger Bacon Drive Suite 406 Reston, VA -

EIN/Tax ID: 262194625
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
Duke University
Suite 710 Erwin Square #7127
2200 W Main Street
Durham, NC 27705-
Contact: Keith Hurka-Owen
Contact Phone: (919) 681-8687