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Design Automation Software for DNA-Based Nano-Sensor Architectures

Award Information

Department of Defense
Office of the Secretary of Defense
Award ID:
Program Year/Program:
2012 / STTR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Celadon Laboratories, Inc.
6525 Belcrest Rd Suite 521 Hyattsville, MD -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2012
Title: Design Automation Software for DNA-Based Nano-Sensor Architectures
Agency / Branch: DOD / OSD
Contract: W911NF-12-C-0060
Award Amount: $749,976.00


A continuing and growing threat to US military personnel and civilians is exposure to toxic chemicals and pathogens. Useful detection systems exist, but it remains imperative to investigate new technologies that have the potential to significantly improve the cost, sensitivity, and size of sensor devices. A promising technology that may achieve these goals is DNA-based nono-sensors. In order for this technology to become viable, it needs automated assay design software. To achieve this, Celadon will collaborate with Dr. David Mathews, an expert in the computation of nucleic acid structures; and with Dr. Jason Kahn, an expert in dna structure and topology and nucleic acid thermodynamics. In Phase I, our team computed databates of optimal helices and loops; developed a heuristic algorithm that obviates the need to evaluate an entire structure; developed a new algorithm for design of psuedo knots, among other deliverables. In Phase II, we will nxnxnxnxnxnxnxnxn

Principal Investigator:

Raymond Peterson
Chief Science Officer
(301) 683-2118

Business Contact:

Lawrence Kessner
Chief Executive Officer
(301) 683-2117
Small Business Information at Submission:

Celadon Laboratories, Inc.
6525 Belcrest Rd Hyattsville, MD -

EIN/Tax ID: 522223222
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
Univ of Rochester+Univ.of Maryland
518 Hylan Building
PO Box 270140
Rochester, NY 14627-0140
Contact: Tammie Martin
Contact Phone: (585) 275-4031