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Compact Chemical Sensor for Measurement of Internal Dose of Environmental Agents

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
R44ES018001
Solicitation Year:
2012
Solicitation Topic Code:
NIEHS
Solicitation Number:
PA11-096
Small Business Information
Agiltron Corporation
15 Presidential Way Woburn, MA 01801-1040
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2012
Title: Compact Chemical Sensor for Measurement of Internal Dose of Environmental Agents
Agency: HHS
Contract: 2R44ES018001-02A1
Award Amount: $986,258.00
 

Abstract:

DESCRIPTION: We propose to build a portable, field-deployable blood test monitor to immediately identify toxic chemical agent buildup in persons suspected of having been exposed to such agents. The technology we plan to utilize is surface- enhanced Raman scattering to look for the presence of environmental agents directly as trace contaminants in the bloodstream. The proposed system is comprised of a low-resolution Raman detection unit coupled to a strip reader that analyzes a drop of blood placed on a goldnanoparticle strip. The low-resolution surface-enhanced Raman spectrum (SERS) obtained from the blood drop on the strip is compared with a spectral peak library in the unit for analysis of the presence and concentration of specific chemical components present in the patient's blood. The Phase II research program is intended to demonstrate on real blood samples the detection capability for a device based on SERS low- resolution Raman methods in a cost-effective, commercially viable configuration. Such a device will be particularly effective in the detection of organic chemical agents in blood, including volatile organic compounds, polybrominated diphenyls (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and toxic industrial chemical exposure such as organophosphonate pesticides, cyanide, and chemical warfare agents and their metabolites. PUBLIC HEALTH RELEVANCE: In the event of an environmental incident, a terrorist threat, or an industrial accident involving toxic industrial chemicals (TIC), rapididentification of the natue of the materials involved and its spread and exposure to the population is essential for proper response. Fast detection and identification of exposure to such threats can provide prompt warning of the extent and severity of theexposure and save many lives by enabling and adopting protective measures. And by identifying the presence of the actual environmental chemical agent or its metabolites promptly and at emerging concentrations, the presence of a threat may be identified and isolated early in the exposure cycle, potentially saving lives in the population at large.

Principal Investigator:

Wayne Weimer
781-935-1200
wweimer@agiltron.com

Business Contact:

Amanda Contardo
781-935-1200
acontardo@agiltron.com
Small Business Information at Submission:

AGILTRON, INC.
15 Presidential Way Woburn, MA -

EIN/Tax ID: 104353958
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No