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Neurocognitive Training to Improve Executive Function

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / STTR
Agency Tracking Number:
R41TR000367
Solicitation Year:
2012
Solicitation Topic Code:
NCATS
Solicitation Number:
PA11-097
Small Business Information
KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
6901 E Fish Lake Road Maple Grove, MN -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: Neurocognitive Training to Improve Executive Function
Agency: HHS
Contract: 1R41TR000367-01A1
Award Amount: $180,718.00
 

Abstract:

DESCRIPTION (provided by applicant): In this Phase I STTR project Koronis Biomedical Technologies (KBT) in close collaboration with the Zelazo Lab at the University of Minnesota proposes to develop an electroencephalography (EEG) based neurocognitive training tool to enable individuals to improve neurocognitive processes associated with executive function (EF). Processes involved in self-control and goal-directed problem solving referred to as Executive Function play an instrumental role in learning and comprise a key protective system for academic resilience in high-risk children. Shortcomings in Executive Function have a higher prevalence in low social economic status children and are correlated to higher rates of incarceration, substance abuse, and loweracademic performance. Neurocognitive training is a form of biofeedback in which real-time measures of brainwave activity are presented to the individual to enable them to willfully control their current mental state. Gamma states (EEG activity above 30Hz)in addition to Beta wavelengths will be detected on the frontal scalp and used to drive custom hardware to provide instantaneous feedback through an innovative mode of action. It is hypothesized that high frequency activity in the prefrontal area is associated with processes implicated in executive function. Advantages of the proposed product when compared to existing commercial EEG-based feedback devices on the market are the following: Executive Function (EF) is the target which has not been the case previously; feedback mode of action is independent of video games and video consoles; device can be used during reading, listening and real-world activities that should greatly improve generalizability and sustainability of improvements to real-world skills and behaviors; improvements in EF will be confirmed with standardized assessments from NIH toolbox and other validated peer-reviewed measures as opposed to subjective parent/teacher ratings. The feasibility of the system will be evaluated in this Phase I project by pursuing four specific aims: 1) Construct a prototype EEG neurocognitive training system for Executive Function improvement; 2) Develop a neurocognitive training regimen consisting of a program of diverse and engaging activities for children and young adolescents; 3) Conduct a pilot human study to assess whether it is possible to increase relative gamma power and other wavelengths over the frontal scalp using EEG neurocognitive training; and 4) use the NIH Toolbox Cognition measures to assess whether improvements are seen in behavior (esp. EF), and whether they are correlated with increases in gamma power or other wavelength patterns. The results from this Phase I project will be used to design a portable prototype to evaluate in clinical studies andto validate and verify requirements of a refined product design for the clinical, school and learning center markets to improve executive function in children. PUBLIC HEALTH RELEVANCE: Neurocognitive processes involved in self-control and goal-directed problem solving referred to as executive function play an instrumental role in learning and comprise a key protective system for resilience in high-risk children. Neurofeedback based on electroencephalography signatures correlated with these neurocognitive processes may provide powerful tools to aid in the development of these cognitive processes and the managing of healthy behaviors. Shortcomings in executive function are characteristic of children with a variety of disorders (e.g., ADHD, Conduct Disorder, autism) and are correlated with higher rates of incarceration, substance abuse, and lower academic performance.

Principal Investigator:

Timothy H. Riehle
612-730-1091
triehle@koronisbiotech.com

Business Contact:

Patrick Lichter
612-730-1091
plichter@koronisbiotech.com
Small Business Information at Submission:

KORONIS BIOMEDICAL TECHNOLOGIES CORPORAT
6901 E. Fish Lake Road Maple Grove, MN -

EIN/Tax ID: 141194323
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF MINNESOTA
UNIVERSITY OF MINNESOTA
100 CHURCH ST SE MINNEAPOLIS, MN 55455
MINNEAPOLIS, MN 55455-
Contact: