USA flag logo/image

An Official Website of the United States Government

SBIR Phase I: Surface Enhanced Raman Scattering Tags for Multiplexed Analysis

Award Information

National Science Foundation
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Nanocomposix, Inc.
4878 Ronson CT STE K San Diego, CA 92111-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2012
Title: SBIR Phase I: Surface Enhanced Raman Scattering Tags for Multiplexed Analysis
Agency: NSF
Contract: 1143416
Award Amount: $150,000.00


This Small Business Innovation Research (SBIR) Phase I project aims to develop Surface Enhanced Raman Scattering (SERS) nanotags for diagnostic and security applications. A novel class of SERS tags that exhibit much higher performance than other tag formulations were demonstrated. This novel class of tags consists of a bimetallic nanoparticle with the Raman-active molecule trapped at the metal/metal junction. In this project, four spectrally distinct SERS tags will be fabricated, coated with silica shells, and functionalized with antibodies to provide specific targeting for diagnostic applications, or with polymers to provide stability in solvents and inks for security applications. Tags will be characterized using a novel high throughput flow spectroscopy instrument capable of analyzing thousands of individual SERS tags, enabling rapid optimization of tag formulations. The performance of optimized tags will be tested in diagnostic and security applications to demonstrate and quantify tag efficacy. The broader/commercial impact of this project will be the potential to provide bright, robust, and spectrally distinct molecules and nanoparticles that can be used to identify and track biologics, people, and products. Currently fluorescent molecules are the most commonly used tag; however, due to their spectral widths, current instrumentation is limited to tracking only 5-20 tags simultaneously. SERS tags, with their very narrow spectral features thus more distinct variants, offer the promise of much higher multiplexing.

Principal Investigator:

Dave Sebba

Business Contact:

Dave Sebba
Small Business Information at Submission:

nanoComposix, Inc.
4878 RONSON CT STE K SAN DIEGO, CA 92111-1806

EIN/Tax ID: 201445921
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No