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Multifunctional Stabilization Matrix for Biological Samples

Award Information

Department of Defense
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Spectrasilk, Inc.
PO Box 53059 Medford, MA 02153
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2012
Title: Multifunctional Stabilization Matrix for Biological Samples
Agency: DOD
Contract: W31P4Q-12-C-0023
Award Amount: $99,962.00


The need for improved biological sample collection and processing for diagnostic applications has grown with the advent of new assays based on small sample sizes and high performance analytics. In contrast to the advances in these analytics, the ability to collect, stabilize, ship and utilize such samples has lagged in terms of development. We offer a relatively simple platform based on recent discoveries of the unique features of silk proteins as remarkably robust stabilization matrices for biological samples. Preliminary data demonstrates remarkable collection and stabilization of labile substrates, such as enzymes, antibodies, vaccines and hemoglobin in the silk matrix, with retention of function over months. This feature derives from the unique protein block copolymer structure of silk, dominated by hydrophobicity with small nanodomains for limited entrained water. This novelty extends well beyond the stabilization features, as the protein is relatively simple to utilize in an aqueous or lyophilized format, can be cast into any form or shape, provides stability of entrapped biologicals over months without refrigeration, can be formed into credit-card formats with optical or Electromagnetic (e.g. RF) features to permit interrogation of the activity of the contents, or can be deconstructed to remove the contents for analysis.

Principal Investigator:

Eun Gil
(339) 221-3038

Business Contact:

Keleigh Sanford
(339) 221-3038
Small Business Information at Submission:

Spectrasilk, Inc.
196 Boston Avenue Suite 1700 Medford, MA -

EIN/Tax ID: 262102996
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No