PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Award Information

Agency: Department of Defense	Branch: N/A	Award ID:	Program Year/Program: 2012 / SBIR
Agency Tracking Number: D121-003-0051	Solicitation Year: 2012	Solicitation Topic Code: SB121-003	Solicitation Number: 2012.1

Small Business Information: Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -
View profile »

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No

Phase 1: Fiscal Year: 2012

Title: PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Agency: DOD

Contract: W911QX-12-C-0074

Award Amount: $99,999.00

Abstract:
Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for the identification of essential and drug resistance genes within the target pathogens. These genes will be used to develop and synthesize PNA based anti-sense oligonucleotides. These PNAs are designed to suppress the growth and destroy the target microorganisms. DNA nanoparticles coated with CPPs will be used to get the anti-sense PNAs into the target microorganisms. Combined, these components will allow for the rapid targeting of essential or drug resistance microbial genes, and the delivery of stable antisense oligonucleotides into the target microorganisms.

Principal Investigator:
Joel Tabb
Principal Scientist
(607) 272-0002
jtabb@agavebio.com

Business Contact:
Noe Salazar
President
(512) 656-6200
nsalazar@agavebio.com

Small Business Information at Submission:

Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -

EIN/Tax ID: 161551819

DUNS: N/A

Number of Employees:

Woman-Owned: No

Minority-Owned: Yes

HUBZone-Owned: Yes