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PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles

Award Information

Department of Defense
Defense Advanced Research Projects Agency
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2012
Title: PNA-Based Rapidly Adaptable Anti-Microbial Nanoparticles
Agency / Branch: DOD / DARPA
Contract: W911QX-12-C-0074
Award Amount: $100,000.00


Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for the identification of essential and drug resistance genes within the target pathogens. These genes will be used to develop and synthesize PNA based anti-sense oligonucleotides. These PNAs are designed to suppress the growth and destroy the target microorganisms. DNA nanoparticles coated with CPPs will be used to get the anti-sense PNAs into the target microorganisms. Combined, these components will allow for the rapid targeting of essential or drug resistance microbial genes, and the delivery of stable antisense oligonucleotides into the target microorganisms.

Principal Investigator:

Joel Tabb
Principal Scientist
(607) 272-0002

Business Contact:

Noe Salazar
(512) 656-6200
Small Business Information at Submission:

Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -

EIN/Tax ID: 161551819
Number of Employees:
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes