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Development of a field-appropriate biosensor for detecting Mycobacterium…

Award Information

Department of Defense
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
NanoRETE, Inc
3815 Technology Blvd Suite 1050 Lansing, MI -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2012
Title: Development of a field-appropriate biosensor for detecting Mycobacterium tuberculosis infection
Agency: DOD
Contract: FA8650-12-M-6249
Award Amount: $150,000.00


Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis (Mtb) that primarily affects the lungs. Approximately one third of the world"s population is latently infected with Mtb and at risk for developing active TB disease. Mtb grows slowly with visible growth appearing on solid media in 3 to 6 weeks. Automated broth systems requires a minimum of 9 days. Currently used rapid diagnostic assays are complex laboratory tests and do not differentiate between latent and active TB infection. There is an urgent need for inexpensive, sensitive, specific, rapid, simple to perform, point-of-care assay for correct TB diagnosis. Phase I research will entail: (1) developing an electrochemical multiplex nano-bead biosensor for measuring plasma cytokine and chemokine concentrations, (2) evaluating the potential of using IFN-Gamma -inducible CXC chemokines as biomarkers of Mtb infection, (3) designing a more refined point-of-care, simple-to-perform assay that is based on the detection of IFN-Gamma-inducible CXC chemokines (used in Phase II), and (4) writing a clinical protocol that will be used in Phase II for preliminary evaluation of the biosensor as an alternative to TST and IGRAs. The proposed immunoassay will facilitate the development of a more accurate, less expensive, point-of-care test for Mtb infection.

Principal Investigator:

Finny Mathew
Sr. Research Scientist/PI
(616) 235-3567

Business Contact:

Prem Bodagala
(616) 235-3567
Small Business Information at Submission:

NanoRETE, Inc
99 Monroe Ave NW Suite 506 Grand Rapids, MI -

EIN/Tax ID: 800712341
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No