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Bioactive Superporous Hydrogels with Vascular Channels for Muscle Tissue…

Award Information

Agency:
Department of Defense
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
O112-H12-3096
Solicitation Year:
2011
Solicitation Topic Code:
OSD11-H12
Solicitation Number:
2011.2
Small Business Information
Luna Innovations Incorporated
1 Riverside Circle Suite 400 Roanoke, VA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: Bioactive Superporous Hydrogels with Vascular Channels for Muscle Tissue Engineering
Agency: DOD
Contract: W81XWH-12-C-0053
Award Amount: $150,000.00
 

Abstract:

There is a substantial clinical need in both civilian and battlefield injuries for the repair and regeneration of large-volume-loss skeletal muscle tissue injuries. Current standards of care rely on rotational tissue grafts and often result in substantial morbidity, pain, and disfigurement. Luna Innovations Incorporated proposes the development of a hierarchically organized, superporous hydrogel construct with aligned vascular channels. The construct formation will utilize a novel sacrificial template for micropore formation in addition to photomasking for vascular channel formation. The scaffolds will be functionalized with a bioactive glycosaminoglycan capable of recruiting and binding important growth factors, extracellular matrix proteins, and progenitor cells. This functionalization will serve to both promote angiogenesis within the construct channels and induce skeletal muscle regeneration by supporting endogenous progenitor cells. Hydrolytically degradable linkages will be introduced through a copolymer addition and degradation rates will be controlled by the addititive ratio. The developed construct will be biodegradable, biocompatible, hierarchically organized and provide both structural and chemical cues for angiogenesis and skeletal muscle tissue regeneration.

Principal Investigator:

Christopher Tison
Principal Investigator
(434) 220-2518
tisonc@lunainnovations.com

Business Contact:

Maggie Hudson
Senior Contracts Administrator
(434) 483-4254
submissions305@lunainnovations.com
Small Business Information at Submission:

Luna Innovations Incorporated
1 Riverside Circle Suite 400 Roanoke, VA -

EIN/Tax ID: 541560050
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No