Non-invasive Detection System for Assessment of Oxidative Status
To address the Army"s need for an innovative concept for non-invasive, compact, robust monitoring system to monitor the oxidative status of military personnel, ChromoLogic (CL) proposes to develop the OCular Oxidative Stress Monitor (OCOSMO) technology based on non-invasive optical measurements of oxidative stress biomarkers that occur within the aqueous humor. The unique scientific expertise of ChromoLogic scientists and collaborators will result in an innovative system that is objective, compact and intuitive to use. In Phase I CL will demonstrate the feasibility of the OCOSMO technology by fabricating a prototype device to demonstrate the concept of Raman spectroscopic monitoring of biomarkers up-regulated in response to oxidative stress within the aqueous. In Phase II, CL plans to develop the OCOSMO device and perform clinical validation of the method.
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