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Universal Bio-Sample Preparation Module

Award Information

Department of Defense
Office for Chemical and Biological Defense
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Physical Optics Corporation
1845 West 205th Street Torrance, CA 90501-1510
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2012
Title: Universal Bio-Sample Preparation Module
Agency / Branch: DOD / CBD
Contract: W911NF-12-C-0047
Award Amount: $726,668.00


Due to increasing recognition of sample preparation as the biggest challenge for biodefense and biomedical detection applications, CBD is seeking a platform technology for automated, universal sample preparation for biosensor systems using small volumes of samples in complex matrices. To address this need, Physical Optics Corporation (POC) proposes to develop a Universal Bio-sample Preparation (UniBioPrep) technology based on the combination of size-exclusion cleansing and dielectrophoretic continuous-flow bio-agent separation technique followed by bio-agent elution and collection. The innovations in the UniBioPrep module will enable the module to perform rapid and automated biological target separation from low volumes of various complex matrices, desalting if needed, concentration, and collection, without the use of labeling or specific reagents. In Phase I, POC demonstrated the feasibility of the UniBioPrep module by developing a benchtop prototype capable of separating and collecting individual classes of biological targets in buffer in<15 minutes. In Phase II, POC will further develop, refine, and validate the UniBioPrep into a module capable of separating the biological targets from complex matrices such as homogenized food, soil, or aqueous samples from an aerosol collector with high yield and purity. At the end of Phase II, the prototype will be at TRL-5 and MRL-4.

Principal Investigator:

Gregory Zeltser
Principal Scientist
(310) 320-3088

Business Contact:

Gordon Drew
Chief Financial Officer
(310) 320-3088
Small Business Information at Submission:

Physical Optics Corporation
Photonic Systems Division 1845 W. 205th Street Torrance, CA -

EIN/Tax ID: 330118051
Number of Employees:
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No