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Development of an in vitro assay as correlate of passive immune protection…

Award Information

Department of Defense
Office for Chemical and Biological Defense
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
5754 PACIFIC CENTER BLVD, #204 SAN DIEGO, CA 92121-4207
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2012
Title: Development of an in vitro assay as correlate of passive immune protection against botulinum neurotoxin to minimize use of whole animal testing
Agency / Branch: DOD / CBD
Contract: W81XWH-11-C-0085
Award Amount: $999,988.00


This Small Business Innovation Research project will develop a non-animal based in vitro assay for determining the efficacy of Botulinum (BoNT) neutralizing therapeutics. New technologies are currently needed in order to facilitate the development and approval of BoNT vaccines and therapies and reduce the number of vertebrate animals used in medical testing. In Phase 1 of this project, the feasibility of the proposed system was demonstrated. During Phase 2, a complete working prototype will now be built, tested and validated against the standard mouse lethality neutralization (MLN) assay. Electronic BioSciences"proposed system will be capable of monitoring the complete neutralizing mechanism of therapies to all seven BoNT serotypes, making rapid, non-animal based neutralization efficacy testing possible.

Principal Investigator:

Eric Ervin
Vice President of R&D
(801) 582-0146

Business Contact:

Tracey E. Wrightson
Director of Operations
(858) 412-1800
Small Business Information at Submission:

Electronic BioSciences INC
5754 Pacific Center Blvd Suite 204 San Diego, CA -

EIN/Tax ID: 274484922
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No