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Deployable Automated Analgesia and Anesthesia System

Award Information

Department of Defense
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Infoscitex Corporation
303 Bear Hill Road Waltham, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 2
Fiscal Year: 2012
Title: Deployable Automated Analgesia and Anesthesia System
Agency: DOD
Contract: W81XWH-11-C-0069
Award Amount: $999,884.00


An automated, closed loop individualized system for administration of analgesic and anesthetic medication to patients is proposed in order to ensure vigilant, optimized care, especially in special circumstances when a large number of trauma patients must be treated simultaneously by a limited number of medical personnel. The result is improved pain management, safety, outcome, and reduced complications such as post-traumatic stress disorder (PTSD). The Deployable Analgesia Administration System (DAAU) optimally sets the infusion rate and rapidly delivers an initial bolus, based on a population pharmacokinetic approach and employs feedback from vital signs monitoring and automated mental status assessment, as well as a novel means to actively query the brain to monitor analgesic/anesthetic depth, in order to safely oversee infusion. A staged product development is proposed, moving from automatic analgesia/anesthesia delivery to the conscious patient, to infusion of medication into patients whose level of consciousness is diminished either by their injuries or requirement for surgical depth of anesthesia. Phase II consists of (1) verification of biomarkers which reflect patient status and their incorporation into medication infusion algorithms, (2) construction and verification of function of a Deployable Autonomous Analgesia Unit (DAAU) prototype, (3) preclinical verification of safety of DAAU in established animal models receiving analgesia/anesthesia from the DAAU, (4) further investigation of a noninvasive sensor for monitoring analgesic/anesthetic depth (as the DAAU adjusts infusion), (5) risk management, and (6) testing to assess ease of use and setup.

Principal Investigator:

James H. Goldie
Principal Investigator
(781) 890-1338

Business Contact:

Cheryl J. Beecher
Sr. Contracts Administrat
(781) 890-1338
Small Business Information at Submission:

Infoscitex Corporation
303 Bear Hill Road Waltham, MA -

EIN/Tax ID: 043537120
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No