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Antimicrobial Drug Targeted to Essential Bacterial Genes in Wound Infection…

Award Information

Department of Defense
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Agave BioSystems, Inc.
401 E. State Street Suite 200 Ithaca, AK 14850-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2012
Title: Antimicrobial Drug Targeted to Essential Bacterial Genes in Wound Infection Pathogens
Agency: DOD
Contract: W81XWH-12-C-0003
Award Amount: $100,000.00


Wounds infected with drug-resistant Gram-negative bacteria can increase morbidity, hospital length of stay and cost. Among these Klebsiella pneumoniae and Pseudomonas aeruginosa have become important causes of concern in military personnel wounded in battlefield. New classes of antimicrobial agents are needed to combat this threat. Emerging work has focused on a new type of strategy through gene silencing by antisense mechanisms to block intracellular synthesis of housekeeping proteins via inhibition of mRNA. Among the various antisense molecules Peptide Nucleic Acids (PNAs) have several advantages and are ideally suited for development as antibacterial agents. PNAs are resistant to nucleases, proteases, and degradative enzymes, have a high binding affinity and a long half-life compared inside the cells compared to antibiotics. Therefore, in this Phase I Agave BioSystems proposes to develop antisense PNA molecules to block synthesis of housekeeping proteins in K. pneumoniae

Principal Investigator:

Mehran Pazirandeh
Staff Scientist
(607) 272-0002

Business Contact:

Noe Salazar
(512) 656-6200
Small Business Information at Submission:

Agave BioSystems, Inc.
P.O. Box 100 Ithaca, NY -

EIN/Tax ID: 161551819
Number of Employees:
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: Yes