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Investigation of CytoSorb cytokine and myoglobin removal in the treatment of…

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
A112-105-0585
Solicitation Year:
2011
Solicitation Topic Code:
A11-105
Solicitation Number:
2011.2
Small Business Information
CYTOSORBENTS, INC.
7 DEER PARK DRIVE, SUITE K MONMOUTH JUNCTION, NJ 99999-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: Investigation of CytoSorb cytokine and myoglobin removal in the treatment of trauma
Agency / Branch: DOD / ARMY
Contract: W81XWH-12-C-0038
Award Amount: $150,000.00
 

Abstract:

Polytrauma is the leading cause of military casualties and is a potent trigger of the immune response. Tissue damage, infection, burns, hemorrhage, ischemia and reperfusion, and cell necrosis triggers the immune system to produce excessive levels of cytokines, often called cytokine storm, that can directly kill cells, damage organs, and cause severe inflammation that ultimately leads to multiple organ failure and death in many patients. In severe trauma, crush injury can further cause the breakdown of skeletal muscle, called rhabdomyolysis, and the vast release of myoglobin that can then injure the kidneys and cause renal failure, an independent risk factor for death. Finally, cytokine storm can also disable the immune system, putting patients at high risk of secondary infections. Because of this, multiple organ failure and infection are two of the main causes of late death in trauma patients, yet remains a problem. In this submission, we propose the development of a portable, self-contained, hemoperfusion system that uses our CytoSorb cytokine and myoglobin filter, to prevent or mitigate organ injury in a porcine model of trauma. If successful, this novel therapy could help improve survival of our warfighters and civilians alike, while reducing healthcare costs.

Principal Investigator:

Phillip Chan
President
(732) 329-8885
pchan@cytosorbents.com

Business Contact:

Humayra Ali
Senior Business Analyst
(732) 329-8885
humayraa@cytosorbents.com
Small Business Information at Submission:

CytoSorbents Inc.
7 Deer Park Drive Suite K Monmouth Junction, NJ -

EIN/Tax ID: 204496406
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No