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Small Molecule Antiviral Agents Against Flaviviruses

Award Information

Department of Defense
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
BIOO Scientific
7050 Burleson Rd. Austin, TX 78744-3202
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2012
Title: Small Molecule Antiviral Agents Against Flaviviruses
Agency: DOD
Contract: W81XWH-12-C-0006
Award Amount: $100,000.00


Flaviviruses are a major health threat worldwide. This family of RNA viruses causes a variety of deadly diseases such as Dengue Fever, Yellow Fever, West Nile virus, and Tick-borne Encephalitis. There are currently no effective means to control these viruses. New drugs to counteract these viruses are desperately needed. Flaviviruses block the body's immune response by inhibiting nuclease enzymes which degrade viral RNA. Our goal is to identify small molecules to disrupt these flavivirus nuclease inhibitors to increase the cell's antiviral response. We will develop a high-throughput fluorescence polarization assay to identify novel small molecule disruptors of the viral inhibitor from compound libraries. We will also identify novel RNA-disrupting compounds using computer modeling techniques. The novel drugs identified will be synthesized and tested using flavivirus-infected cells in tissue culture to confirm biological activity.

Principal Investigator:

Joseph Krebs
(512) 707-8993

Business Contact:

Lance Ford
(512) 707-8993
Small Business Information at Submission:

BIOO Scientific
3913 Todd Lane Suite 312 Austin, TX -

EIN/Tax ID: 870781699
Number of Employees:
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No