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Nano-Therapeutics for Secondary Lymphedema

Award Information

Department of Defense
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
Physical Optics Corporation
Electro-Optics Systems Division 1845 West 205th Street Torrance, CA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2012
Title: Nano-Therapeutics for Secondary Lymphedema
Agency: DOD
Contract: W81XWH-12-C-0098
Award Amount: $99,977.00


To address the U.S. Army need for a curative treatment for secondary lymphedema that will restore the function of the lymphatic vessel system by stimulating lymphangiogenesis, Physical Optics Corporation (POC) proposes to develop a Nano-Therapeutics for Secondary Lymphedema (NATSEL). The NATSEL will include a nanocarrier (NC) loaded with VEGF-C and ANG-2, a biocompatible gel to contain the NC and a microneedle patch for transdermal delivery of the therapeutic. The innovations in NATSEL will enable minimally invasive targeted delivery of the VEGF-C and ANG-2 to the lymphatic endothelial cells. The NATSEL modality has minimal toxicity and immunogenicity profiles and is easy to administer. In Phase I, POC will demonstrate the feasibility of the NATSEL concept by developing a prototype that can stimulate lymphangiogenesis in appropriate cell culture, resulting in lymphatic endothelial cell proliferation, migration, and tube formation and branching. In Phase II, POC plans to demonstrate, optimize, and validate the NATSEL therapeutic strategy in animal models of secondary lymphedema. The FDA approval pathway will be outlined and considered at each developmental stage.

Principal Investigator:

Gregory Zeltser
Principal Scientist
(310) 320-3088

Business Contact:

Gordon Drew
Chief Financial Officer
(310) 320-3088
Small Business Information at Submission:

Physical Optics Corporation
Photonic Systems Division 20600 Gramercy Place, Bldg. 100 Torrance, CA -

EIN/Tax ID: 330118051
Number of Employees:
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No