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Development of a High Performance Bioprocess for Eliminating 1,4-Dioxane in…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
R43ES022123
Solicitation Year:
2012
Solicitation Topic Code:
NIEHS
Solicitation Number:
PA11-096
Small Business Information
MICROVI BIOTECH, INC.
26229 EDEN LANDING RD STE 1 Hayward, CA 94545-3702
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2012
Title: Development of a High Performance Bioprocess for Eliminating 1,4-Dioxane in Water
Agency: HHS
Contract: 1R43ES022123-01
Award Amount: $130,959.00
 

Abstract:

DESCRIPTION (provided by applicant): Across the United States, water suppliers and managers are finding dangerous levels of 1,4-dioxane in water. This compound has been used for decades in a wide range of applications including as (1) a solvent in paints,varnishes, and prints; (2) treatment agent in artificial leather, (3) ingredient in pesticides and fumigants, (4), purifying agent in pharmaceuticals, and (5) solvent in resins, oils, plastics, adhesives, waxes, and cement. 1,4-dioxane is a probable humancarcinogen at extremely low levels in water (parts-per-billion). It is highly soluble and thus travels extensively in underground water systems Most importantly, no conventional water treatment technologies can remove 1,4-dioxane from water. There are only two routes of eliminating 1,4- dioxane in water: UV or hydrogen peroxide coupled with ozone oxidation (i.e. advanced oxidation), and biological degradation. The energy and chemical costs of UV and chemical oxidation processes are often prohibitively high. There is also a significant risk of producing harmful by-products (such as carcinogenic bromate) and these technologies have limited applicability in certain circumstances Biological degradation also suffers from a number of drawbacks, including processstability, the need to induce degradation, limited performance, clogging, performance sensitivity, and the production of sludge or secondary waste streams. If these problems can be overcome, however, biological treatment offers a promising method of completely degrading 1,4-dioxane into harmless products and ensuring the integrity of the environment. The proposed research is founded on two novel discoveries. First, a high-rate biological treatment pathway has been found that apparently does not require pre-induction. This discovery may significantly simplify the treatment process. Second, this pathway can be utilized in a new high performance bioprocess that may overcome most or all of the engineering obstacles faced by conventional biological treatments. Specifically, the proposed research builds on and certifies these initial successes by conducting a series of laboratory (kinetic) experiences using 1,4-dioxane alone and in the presence of a co-contaminant, trichloroethylene (TCE). A continuous-flow bioreactor prototype is then designed and constructed. This model is tested extensively over several months using actual groundwater from a contaminated site to determine its specific performance under a range of operating conditions. These performance parametersare used to design a larger pilot-scale reactor that will undergo further refining in a field site in the next phase of research. The primary intended outcome of this research is a high performance bioprocess for eliminating 1,4-dioxane in water resources. Based on successful preliminary studies, it is expected that this new technology will be simpler, more effective, and less costly than any 1,4-dioxane treatment technology available on the market today. Most importantly, the research is intended to provide a valuable tool for protecting and remediating drinking water supplies, thus safeguarding public safety and environmental sustainability. PUBLIC HEALTH RELEVANCE: The quality of our drinking water is directly linked to human health and safety.A probable human carcinogen, 1,4-dioxane, has been found across the United States and we currently lack effective technologies to mitigate the threat it poses. This proposal aims to meet this need by developing a novel high performance water technology todegrade 1,4-dioxane into harmless products, thus protecting public health.

Principal Investigator:

Joseph Salanitro
913-696-9934
jsalanitro@microvibiotech.com

Business Contact:

Farhad Dorri
510-344-0668
fdorri@microvibiotech.com
Small Business Information at Submission:

MICROVI BIOTECH, INC.
26229 Eden Landing Rd Hayward, CA 94545-

EIN/Tax ID: 180021069
DUNS: N/A
Number of Employees: N/A
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No